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Androgens, or male hormones such as testosterone, are necessary for normal growth and development of the prostate, the researchers said, but noted that the same androgens are also suspected of playing a role in prostate cancer. "Whether they act as initiators ... or as promoters is debatable," the team reported. Most investigators agree that male hormones play a role, however, in either the development of prostate cancer or its progression. Believing that oxidative stress causes the male hormones to contribute to age-associated increase in prostate cancer and subsequent prostate cancer treatment, the researchers turned to two antioxidant vitamins known to inhibit oxidative stress, Vitamins C and E. Noting that previous studies of antioxidants had provided encouraging data on prostate cancer treatment prevention, the University of Wisconsin team turned to a combination of the two vitamins to test whether they could influence the adverse effects of androgens, and found that the androgen activity was "diminished by Vitamins C and E." The earlier studies included reports that long-term intake of Vitamin E in supplement form reduced prostate cancer incidence by 32 percent and reduced prostate cancer deaths by 41 percent in cigarette smokers. The new findings, showing that the combined Vitamins C and E reduced the effects of the androgens to stimulate prostate cancer cells, merit further study, the researchers said. "Defining the pathways involving androgens, oxidative stress and prostate carcinogenesis and determining the capacity of antioxidants to favorably intervene appear to be topics worthy of further pursuit," the research team concluded. (Foods for the Future provides factual information to the media concerning food products, health and nutrition. It is a project of the T. Dean Reed Company and is supported by U.S. agribusiness.) SOURCE Foods for the Future
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